The Greenland Ice Sheet loses 30 %–60 % of its ice due to iceberg calving. Calving processes and their links to climate are not well understood or incorporated into numerical models of glaciers. Here we use a new 3-D calving model to investigate calving at Store Glacier, West Greenland, and test its sensitivity to increased submarine melting and reduced support from ice mélange (sea ice and icebergs). We find Store remains fairly stable despite these changes, but less so in the southern side.